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  24 2025-04

  Advancing autism research: Insights from brain organoid modeling

  Chong V. Li, Jürgen A. Knoblich, Advancing autism research: Insights from brain organoid modeling, Current Opinion in Neurobiology, Volume 92, 2025, 103030, ISSN 0959-4388, doi: 10.1016/j.conb.2025.103030.

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  18 2024-09

  A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids

  Bosone C, Castaldi D, Burkard TR, Guzman SJ, Wyatt T, Cheroni C, Caporale N, Bajaj S, Bagley JA, Li C, Sorre B, Villa CE, Testa G, Krenn V, Knoblich JA. A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids. Nat Methods. 2024 Nov;21(11):2147-2159. doi: 10.1038/s41592-024-02412-5.

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  13 2023-09

  Single-cell brain organoid screening identifies developmental defects in autism

  Li C*#, Fleck J S*, Martins-Costa C, Burkard T R, Stuempflen M, Vertesy Á, Peer A M, Esk C, Elling U, Kasprian G, Corsini N S, Treutlein B# and Knoblich J A#. (2023) Single-cell brain organoid screening identifies developmental defects in autism. Nature 621, 373–380 (*equal contribution, # co-corresponding)

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  17 2021-12

  NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

  Liu J, Tao X, Zhu Y, Li C, Ruan K, Diaz-Perez Z, Rai P, Wang H, Zhai RG. (2021) NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. Elife. 2021 Dec 17;10:e70046. doi: 10.7554/eLife.70046.

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  06 2020-04

  Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

  Ma X, Zhu Y, Lu J, Xie J, Li C, Shin WS, Qiang J, Liu J, Dou S, Xiao Y, Wang C, Jia C, Long H, Yang J, Fang Y, Jiang L, Zhang Y, Zhang S, Zhai RG, Liu C, Li D. (2020) Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau. Elife. Apr 6;9:e51859. doi: 10.7554/eLife.51859.

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  04 2019-09

  Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

  Zhu Y, Li C, Tao X, Brazill JM, Park J, Diaz-Perez Z, Zhai RG (2019) Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity. PNAS, 116 (38), 19165-19175

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  30 2019-08

  MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing

  Park J, Zhu Y, Tao X, Brazill JM, Li C, Wuchty S, Zhai RG (2019) Microrna mir-1002 enhances Nmnat-mediated stress response by modulating alternative splicing. iScience, 19:1048-1064.

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  04 2019-01

  Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

  Li C*, Bademci G*, Subasioglu A, Diaz-Horta O, Zhu Y, Liu J, Mitchell TG, Abad C, Seyhan S, Duman D, Cengiz FB, Tokgoz-Yilmaz S, Blanton SH, Farooq A, Walz K, Zhai RG, Tekin M (2019) Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. (*equal contribution), PNAS, 116: 1347-1352

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  03 2018-08

  Quantitative cell biology of neurodegeneration in Drosophila through unbiased analysis of fluorescently tagged proteins using ImageJ

  Brazill J, Zhu Y, Li C, Zhai RG (2018) Quantitative cell biology of neurodegeneration in Drosophila through unbiased analysis of fluorescently tagged proteins using ImageJ. J. Vis. Exp. (138), e58041, doi:10.3791/58041.

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  02 2017-11

  Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

  Li C, Brazill J, Liu S, Bello C, Zhu Y, Morimoto M, Cascio L, Pauly R, Diaz-Perez Z, Malicdan MCV, Wang H, Boccuto L, Schwartz CE, Gahl WA, Boerkoel CF, Zhai RG (2017) Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. Nature Communications, 8(1):1257

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  26 2017-05

  Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience

  Gall T, Valkanas E, Bello C, Markello T, Adams C, Bone WP, Brandt AJ, Brazill JM, Carmichael L, Davids M, Davis J, Diaz-Perez Z, Draper D, Elson J, Flynn ED, Godfrey R, Groden C, Hsieh C-K, Fischer R, Golas GA, Guzman J, Huang Y, Kane MS, Lee E, Li C, Links AE, Maduro V, Malicdan MCV, Malik FS, Nehrebecky M, Park J, Pemberton P, Schaffer K, Simeonov D, Sincan M, Smedley D, Valivullah Z, Wahl C, Washington N, Wolfe LA, Xu K, Zhu Y, Gahl WA, Tifft CJ, Toro C, Adams DR, He M, Robinson PN, Haendel MA, Zhai RG and Boerkoel CF (2017) Defining disease, diagnosis, and translational medicine within a homeostatic perturbation paradigm: The NIH Undiagnosed Diseases Program experience. Front. Med., 4:62.

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  23 2017-04

  NMNAT: It’s an NAD+ Synthase… It’s a chaperone… It’s a neuroprotector.

  Brazill JM*, Li C*, Zhu Y*, Zhai RG (2017) NMNAT: It’s an NAD+ Synthase… It’s a chaperone… It’s a neuroprotector. Curr Opin Genetics Dev., 44:156–162. (*Equal contribution).

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  26 2016-07

  Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging.

  Ruetenik A, Ocampo A, Ruan K, Zhu Y, Li C, Zhai RG and Barrientos A (2016) Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging. Microbial Cell 3(8):338-351.

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  30 2015-11

  Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

  Ruan K, Zhu Y*, Li C*, Brazill J, and Zhai RG (2015) Alternative splicing of Drosophila Nmnat acts as a switch to enhance neuroprotection under stress. Nature Communications 6:10057 (*Equal contribution)